Patientenkolloquium 2019
Das Universitätsklinikum Bonn möchte Sie auch 2019 wieder für das Patientenkolloquium "Uni-Medizin für Sie: Mitten im Leben" herzlich einladen ... weiterlesen

2. AG Prof. Dr. B. Pötzsch

Research interests
Despite the increasing knowledge about the cellular and molecular mechanisms involved in the activation and regulation of the hemostatic network there are a variety of major challenges and unresolved problems in day-to-day care of patients presenting with hemostatic disorders. The research activities of the group are focused on the identification of disease-related phenotypes of the hemostatic system allowing development of improved treatment strategies such as personalized anticoagulant treatment. Active metabolites of the hemostatic system, such as thrombin and activated protein C, are promising candidates to more precisely define the activity state of the hemostatic system in vivo. In close cooperation with the group of Günter Mayer of the Life and Medical Sciences Institute (LIMES) we make use of aptamers to develop knew diagnostic platforms allowing detection of active clotting factors.
On-going projects
Selection and characterization of aptamers targeting coagulation factors
Development of oligonucleotide-based assay platforms for the measurement of active clotting factors
Determination of the prothrombotic profile of antiphospholipid antibodies
Coagulation profiling during oestrogen-replacement therapy
Imaging of hemostasis profiles in patients undergoing major surgical interventions

Cooperation partners
Prof. Dr. G. Mayer, Life and Medical Sciences Institute, University of Bonn
Prof. Dr. W. Kuhn, Department of Gynaecology and Obstetrics of the University Hospital Bonn
Prof. Dr. H.P. Fischer, Institute of Pathology, University of Bonn

Bernd Pötzsch,
Jens Müller,

For more information see

Stand: 14. Oktober 2014